Navarro Juan F, Mora Carmen
Nephrology Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
ScientificWorldJournal. 2006 Aug 9;6:908-17. doi: 10.1100/tsw.2006.179.
Diabetes and its complications have become a public health problem. Diabetic nephropathy is the main cause of renal failure. In spite of our higher knowledge on this complication, the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, inflammation, and more specifically proinflammatory cytokines and other molecules with a relevant role within the inflammatory process, may be critical factors in the development of microvascular diabetic complications, including nephropathy. This new pathogenic perspective may lead to important new therapeutic considerations and new therapeutic goals for the treatment of diabetic nephropathy.
糖尿病及其并发症已成为一个公共卫生问题。糖尿病肾病是肾衰竭的主要原因。尽管我们对这一并发症有了更多了解，但导致肾损伤发生和进展的内在机制仍未完全明确。激活的固有免疫和炎症是糖尿病发病机制中的相关因素。此外，炎症，更具体地说是促炎细胞因子和在炎症过程中起相关作用的其他分子，可能是包括肾病在内的糖尿病微血管并发症发生的关键因素。这种新的致病观点可能会为糖尿病肾病的治疗带来重要的新治疗思路和新治疗目标。
