Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
J Leukoc Biol. 2018 Nov;104(5):919-923. doi: 10.1002/JLB.MR1217-489R. Epub 2018 Jul 12.
Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
慢性肾脏病及其并发症是全球范围内的一个主要公共卫生问题。糖尿病肾病已成为终末期肾衰竭的主要致病原因。目前有证据表明，包括促炎细胞因子在内的不同炎症分子在微血管糖尿病并发症（包括肾病）的发展中起着关键作用。IL-20 作为一种与几种慢性炎症性疾病（如银屑病、动脉粥样硬化和肾衰竭）相关的强效血管生成、趋化和促炎细胞因子，正逐渐受到关注。本综述讨论了 IL-20 作为肾脏损伤致病因子的作用，重点讨论了慢性肾脏病和糖尿病肾病，并描述了基于调节 IL-20 功能的潜在治疗策略。
