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Cloned transgenic heart-healthy pork?

作者信息

Prather Randall S

机构信息

Division of Animal Sciences, University of Missouri-Columbia, 920 East Campus Drive, E125 Animal Science Research centre, Columbia, MO 65211, USA.

出版信息

Transgenic Res. 2006 Aug;15(4):405-7. doi: 10.1007/s11248-006-0022-3.

DOI:10.1007/s11248-006-0022-3
PMID:16906441
Abstract

Here I comment on the production and uses of swine that express a humanized fat-1 gene. The gene product is a fatty acid desaturase that converts omega-6 fatty acids to omega-3 fatty acids. Omega-3 fatty acids have been implicated as being important for reproductive success, maintaining a healthy cardiovascular system, sustaining a functional immune system, and even preventing depression and cancer. The descendants of these hfat-1 transgenic swine will be very useful as models of the human condition, and if they are permitted to enter the food chain, they may improve human health.

摘要

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本文引用的文献

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组蛋白去乙酰化酶抑制剂可提高体细胞核移植猪胚胎的体外和体内发育能力。
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Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.通过使用携带杂合性缺失突变的成纤维细胞进行核移植来生产α-1,3-半乳糖基转移酶基因敲除猪。
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Nature. 2004 Feb 5;427(6974):504. doi: 10.1038/427504a.
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Phenotyping of transgenic cloned piglets.转基因克隆仔猪的表型分析。
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