Keikhaee Mohammad Reza, Hashemi Susan Bany, Najmabadi Hossein, Noroozian Maryam
Genetics Research Center, Social Welfare and Rehabilitation Sciences University, Tehran, Iran.
Neurochem Res. 2006 Aug;31(8):1079-83. doi: 10.1007/s11064-006-9119-6. Epub 2006 Aug 12.
In recent years numerous data suggest that vascular risk factors may be play a role in Alzheimer's disease (AD). To determine the association of AD with methylentetrahydrofulate reductase (MTHFR) and angiotensin converting enzyme (ACE) as two main vascular risk factors, we examined MTHFR C677T and ACE insertion/deletion (I/D) gene polymorphism in 117 late-onset AD cases and 125 controls. We found no difference in ACE I/D genotype distribution between AD cases and control (P > 0.05) but there was a significant association between AD and the common MTHFR polymorphism C677T. The T allele conferred an increased risk of AD compared to carrying a C allele (P = 0.001, OR = 1.97, 95% CI: 1.3-2.09). Our result suggests a significant increase in risk of AD in cases with the MTHFR T allele, atleast in the Iranian population.
近年来，大量数据表明血管危险因素可能在阿尔茨海默病（AD）中起作用。为了确定AD与作为两个主要血管危险因素的亚甲基四氢叶酸还原酶（MTHFR）和血管紧张素转换酶（ACE）之间的关联，我们检测了117例晚发性AD患者和125例对照者的MTHFR C677T和ACE插入/缺失（I/D）基因多态性。我们发现AD患者和对照者之间ACE I/D基因型分布没有差异（P>0.05），但AD与常见的MTHFR多态性C677T之间存在显著关联。与携带C等位基因相比，T等位基因使AD风险增加（P = 0.001，OR = 1.97，95%CI：1.3 - 2.09）。我们的结果表明，至少在伊朗人群中，携带MTHFR T等位基因的个体患AD的风险显著增加。
