Leitenberger A, Altwein J E
Urologische Abteilung, Krankenhaus der Barmherzigen Brüder, München, BRD.
Eur Urol. 1990;17(1):12-6. doi: 10.1159/000463990.
A study was performed on 175 men to compare the level of prostate-specific antigen (PSA) in patients with benign prostatic hyperplasia (n = 83) and prostatic carcinoma (n = 92). There was a good correlation between T stage and increasing values of PSA. Using 2.5 ng/ml as the upper normal limit of PSA, the test sensitivity of PSA was 94%, but the specificity only 44%. Receiver-operator characteristic curve (ROC) analysis demonstrates that PSA is superior to prostatic acid phosphatase (PAP); this is particularly true in the higher T stages. Although ROC analysis shows that PSA is more discriminating than PAP, the sensitivity of PSA is dependent upon the choice of an appropriate cut-off point of the test. It was shown that PSA is not sufficient for detecting the presence or absence of prostatic cancer in a general population. However, PSA is the most sensitive marker in the detection of prostatic cancer.
对175名男性进行了一项研究，以比较良性前列腺增生患者（n = 83）和前列腺癌患者（n = 92）的前列腺特异性抗原（PSA）水平。T分期与PSA值升高之间存在良好的相关性。以2.5 ng/ml作为PSA的正常上限，PSA的检测敏感性为94%，但特异性仅为44%。受试者工作特征曲线（ROC）分析表明，PSA优于前列腺酸性磷酸酶（PAP）；在较高的T分期中尤其如此。尽管ROC分析表明PSA比PAP更具鉴别力，但PSA的敏感性取决于检测合适临界值的选择。结果表明，PSA不足以在普通人群中检测前列腺癌的有无。然而，PSA是检测前列腺癌最敏感的标志物。
