Li MengRu, Greenside Henry
Department of Physics, Duke University, Durham, North Carolina 27708-0305, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jul;74(1 Pt 1):011918. doi: 10.1103/PhysRevE.74.011918. Epub 2006 Jul 26.
We demonstrate numerically that a brief burst consisting of two to six spikes can propagate in a stable manner through a one-dimensional homogeneous feedforward chain of nonbursting neurons with excitatory synaptic connections. Our results are obtained for two kinds of neuronal models: leaky integrate-and-fire neurons and Hodgkin-Huxley neurons with five conductances. Over a range of parameters such as the maximum synaptic conductance, both kinds of chains are found to have multiple attractors of propagating bursts, with each attractor being distinguished by the number of spikes and total duration of the propagating burst. These results make plausible the hypothesis that sparse, precisely timed sequential bursts observed in projection neurons of nucleus HVC of a singing zebra finch are intrinsic and causally related.
我们通过数值模拟证明，由两到六个尖峰组成的短暂脉冲串能够以稳定的方式在具有兴奋性突触连接的一维均匀前馈非爆发性神经元链中传播。我们针对两种神经元模型获得了结果：漏电积分发放神经元和具有五种电导的霍奇金-赫胥黎神经元。在一系列参数范围内，如最大突触电导，发现这两种神经元链都有多个传播脉冲串的吸引子，每个吸引子由传播脉冲串的尖峰数量和总持续时间来区分。这些结果使这样的假设变得合理：在鸣禽斑胸草雀HVC核的投射神经元中观察到的稀疏、精确计时的连续脉冲串是内在的且存在因果关系。
