Kitajima Naoharu, Sugita-Kitajima Akemi, Bai Rishu, Sasaki Mitsuyoshi, Sato Hitoshi, Imagawa Midori, Kawamoto Eiichi, Suzuki Mamoru, Uchino Yoshio
Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Neurosci Lett. 2006 Oct 2;406(1-2):1-5. doi: 10.1016/j.neulet.2006.06.024. Epub 2006 Aug 14.
Using collision tests of orthodromically and antidromically generated spikes, we studied the axonal pathways, axonal projection levels, and soma location of anterior semicircular canal (AC) nerve-activated vestibulospinal neurons in decerebrate cats. AC nerve-activated vestibulospinal neurons (n=74) were mainly located in the ventral portion of the lateral vestibular nuclei and the rostral portion of the descending vestibular nucleus, which is consistent with previous studies. Of these neurons, 15% projected through the ipsilateral (i-) lateral vestibulospinal tract (LVST), 74% projected through the medial vestibulospinal tract (MVST), and 11% projected through the contralateral (c-) LVST. The vast majority (78%) of AC nerve-activated vestibulospinal neurons were activated antidromically only from the cervical segment of the spinal cord; 15% of neurons were activated from the T1 segment and only one neuron was activated from the L3 segment. AC nerve-activated vestibulospinal neurons may primarily target the neck muscles and thus contribute to the vestibulocollic reflex. Most of the c-LVST neurons were also activated antidromically from the oculomotor nucleus, suggesting that they are closely related to the control of combined eye-head movements.
利用顺向和逆向产生的锋电位的碰撞试验，我们研究了去大脑猫中前半规管（AC）神经激活的前庭脊髓神经元的轴突通路、轴突投射水平和胞体位置。AC神经激活的前庭脊髓神经元（n = 74）主要位于外侧前庭核的腹侧部分和下行前庭核的 Rostral 部分，这与先前的研究一致。在这些神经元中，15%通过同侧（i-）外侧前庭脊髓束（LVST）投射，74%通过内侧前庭脊髓束（MVST）投射，11%通过对侧（c-）LVST 投射。绝大多数（78%）AC 神经激活的前庭脊髓神经元仅从脊髓颈段被逆向激活；15%的神经元从 T1 节段被激活，只有一个神经元从 L3 节段被激活。AC 神经激活的前庭脊髓神经元可能主要靶向颈部肌肉，从而有助于前庭颈反射。大多数 c-LVST 神经元也从动眼神经核被逆向激活，这表明它们与联合眼-头运动的控制密切相关。
