Pironi L, Paganelli F, Lauro A, Spinucci G, Guidetti M, Pinna A D
Intestinal Failure Centre of the Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico Sant'Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy.
Transplant Proc. 2006 Jul-Aug;38(6):1673-5. doi: 10.1016/j.transproceed.2006.05.035.
We compared the health related quality of life (HRQOL) of stable patients on home parenteral nutrition (HPN) and of patients who underwent successful intestinal transplantation (ITx).
HRQOL was evaluated by the non-disease-specific Short Form 36 instrument, which examines eight specific domains and scores them on a scale of 0% to 100%. Patient scores were standardized for the sex-matched and age-matched group scores of the healthy population by calculating the Z-score (reduced value: Z-score < -1).
Eighteen patients on HPN and 12 patients who underwent ITx were studied. The two groups did not differ for primary intestinal disease, cause of intestinal failure, presence of a stoma, body mass index, and employment and marital status. HPN Z-scores were physical functioning -2.3, physical role -1.5, body pain -1.0, general health -1.2, vitality -0.5, social functioning -0.9, emotional role -0.7, and mental health 0.0. ITx Z-scores were physical functioning -1.7, physical role -0.8, body pain 0.0, general health -0.4, vitality 0.0, social functioning -0.4, emotional role -0.3, and mental health 0.0. Only the body pain Z-scores differed significantly (P = .012).
The value of the physical components of the SF-36 was reduced in all the components in the HPN patients and in the physical functioning component in the ITx patients. The mental health components were normal in both. Successful ITx showed a better subjective physical health feeling than stable HPN.
我们比较了接受家庭肠外营养（HPN）的稳定患者与接受成功肠移植（ITx）患者的健康相关生活质量（HRQOL）。
采用非疾病特异性的简明健康状况调查量表（Short Form 36）评估HRQOL，该量表检测八个特定领域，并在0%至100%的范围内对其进行评分。通过计算Z评分（降低值：Z评分 < -1），将患者得分按照健康人群的性别匹配和年龄匹配组得分进行标准化。
研究了18例接受HPN的患者和12例接受ITx的患者。两组在原发性肠道疾病、肠衰竭原因、造口的存在、体重指数以及就业和婚姻状况方面没有差异。HPN组的Z评分分别为：身体功能-2.3、身体角色-1.5、身体疼痛-1.0、总体健康-1.2、活力-0.5、社会功能-0.9、情感角色-0.7和心理健康0.0。ITx组的Z评分分别为：身体功能-1.7、身体角色-0.8、身体疼痛0.0、总体健康-0.4、活力0.0、社会功能-0.4、情感角色-0.3和心理健康0.0。只有身体疼痛的Z评分有显著差异（P = 0.012）。
SF-36身体成分的值在HPN患者的所有成分以及ITx患者的身体功能成分中均降低。两组的心理健康成分均正常。成功的ITx显示出比稳定的HPN更好的主观身体健康感受。
