乌司他丁对大鼠小肠移植受体术后全身炎症反应的影响。
Effects of ulinastatin on postoperative systemic inflammatory response of recipients of rat small bowel transplantation.
作者信息
Sun J-L, Zhang X-Q, Yu Z-G, Ma R, Dai Y, Fan Z-Y, Sun J-Z
机构信息
Department of Operation, Qilu Hospital of Shandong University, Shandong, China.
出版信息
Transplant Proc. 2006 Jul-Aug;38(6):1803-4. doi: 10.1016/j.transproceed.2006.06.084.
AIM
We sought to evaluate the effects of ulinastatin on postoperative systemic inflammatory responses of recipients of rat small bowel transplantations (SBT).
METHODS
Twenty-four recipients of rat heterotopic SBT were randomly divided into a control group and a treated group. Ulinastatin (50,000 U/kg(-1)/d(-1)) was injected intravenously 30 minutes before graft revascularization. Measured variables included plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and C-reactive protein (CRP) on postoperative days 1 and 3.
RESULTS
Administration of ulinastatin attenuated the postoperative increases in plasma concentrations of TNF, IL-6, and CRP.
CONCLUSION
Ulinastatin attenuated the postoperative systemic inflammatory response of rat recipients of SBT.
目的
我们试图评估乌司他丁对大鼠小肠移植（SBT）受体术后全身炎症反应的影响。
方法
将24只大鼠异位SBT受体随机分为对照组和治疗组。在移植物血管再通前30分钟静脉注射乌司他丁（50,000 U/kg⁻¹/d⁻¹）。测量的变量包括术后第1天和第3天血浆中肿瘤坏死因子（TNF）、白细胞介素（IL）-6和C反应蛋白（CRP）的浓度。
结果
乌司他丁的给药减轻了术后血浆中TNF、IL-6和CRP浓度的升高。
结论
乌司他丁减轻了大鼠SBT受体术后的全身炎症反应。
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