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HIV envelope glycoprotein, antigen specific T-cell responses, and soluble CD4.

作者信息

Manca F, Habeshaw J A, Dalgleish A G

机构信息

Department of Immunology, University of Genoa, San Martino Hospital, Italy.

出版信息

Lancet. 1990 Apr 7;335(8693):811-5. doi: 10.1016/0140-6736(90)90935-x.

DOI:10.1016/0140-6736(90)90935-x
PMID:1690832
Abstract

Specific T cells stimulated by antigen presenting cells (APC) pulsed with antigen in the presence of HIV were no longer detectable with a functional assay, which suggests that HIV has been transferred from APC to the specific activated T cell via an antigen-dependent mechanism to exert its cytopathic effect on activated T cells. In contrast soluble gp120 inhibited antigen-driven proliferation, but this action was reversible and could be blocked by soluble CD4. Thus the chief mechanism of HIV pathogenesis may be gp120/CD4 interaction and HIV may be pathogenic mainly as a producer of gp120.

摘要

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