HIV-1感染中的免疫失调与CD4+ T细胞损失。 - Suppr

Immune dysregulation and CD4+ T cell loss in HIV-1 infection.

作者信息

Meyaard L, Miedema F

机构信息

Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

出版信息

Springer Semin Immunopathol. 1997;18(3):285-303. doi: 10.1007/BF00813499.

DOI:10.1007/BF00813499

PMID:9089950

Abstract

摘要

相似文献

Immune dysregulation and CD4+ T cell loss in HIV-1 infection.HIV-1感染中的免疫失调与CD4+ T细胞损失。

Springer Semin Immunopathol. 1997;18(3):285-303. doi: 10.1007/BF00813499.

Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells.静息外周血T细胞暴露于HIV-1颗粒会在一小部分细胞中产生CD25+杀伤细胞，从而导致旁观者细胞发生凋亡。

Int Immunol. 1997 Oct;9(10):1453-62. doi: 10.1093/intimm/9.10.1453.

Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children.1型人类免疫缺陷病毒（HIV-1）感染儿童中的抗CD95（APO-1/Fas）自身抗体与T细胞耗竭

Cell Death Differ. 1998 Mar;5(3):222-30. doi: 10.1038/sj.cdd.4400332.

Programmed death of T cells in HIV infection: result of immune activation?HIV感染中T细胞的程序性死亡：免疫激活的结果？

Curr Top Microbiol Immunol. 1995;200:213-21. doi: 10.1007/978-3-642-79437-7_15.

Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss.抗逆转录病毒治疗期间的不一致反应：免疫激活和T细胞重新分布而非真正的CD4 T细胞丢失的作用

AIDS. 2002 Jun 14;16(9):1287-9. doi: 10.1097/00002030-200206140-00013.

HIV-1 evolution and disease progression.HIV-1的演变与疾病进展。

Science. 1996 Nov 8;274(5289):1008-11. doi: 10.1126/science.274.5289.1008.

The independent effect of drug resistance on T cell activation in HIV infection.耐药性对HIV感染中T细胞活化的独立影响。

AIDS. 2006 Mar 21;20(5):691-9. doi: 10.1097/01.aids.0000216369.30948.18.

Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes.细胞因子信号足以使HIV-1感染静息的人类T淋巴细胞。

J Exp Med. 1999 Jun 7;189(11):1735-46. doi: 10.1084/jem.189.11.1735.

Increased soluble Fas in HIV-infected hemophilia patients with CD4+ and CD8+ cell count increases and viral load and immune complex decreases.在HIV感染的血友病患者中，随着CD4+和CD8+细胞计数增加、病毒载量和免疫复合物减少，可溶性Fas增加。

AIDS Res Hum Retroviruses. 2001 Mar 1;17(4):329-35. doi: 10.1089/08892220150503690.

Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.CD28共刺激对HIV阳性患者的抗病毒作用及体外CD4 + T细胞增殖的影响

Science. 1996 Jun 28;272(5270):1939-43. doi: 10.1126/science.272.5270.1939.

引用本文的文献

Immune Checkpoints in Viral Infections.病毒感染中的免疫检查点。

Viruses. 2020 Sep 21;12(9):1051. doi: 10.3390/v12091051.

Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.1型人类免疫缺陷病毒对外周血CD4(+) T淋巴细胞的细胞病变杀伤似乎是坏死性的而非凋亡性的，并且不需要env。

J Virol. 2002 May;76(10):5082-93. doi: 10.1128/jvi.76.10.5082-5093.2002.

Intestinal intraepithelial lymphocytes are primed for gamma interferon and MIP-1beta expression and display antiviral cytotoxic activity despite severe CD4(+) T-cell depletion in primary simian immunodeficiency virus infection.在原发性猿猴免疫缺陷病毒感染中，尽管存在严重的CD4(+) T细胞耗竭，但肠道上皮内淋巴细胞仍准备好表达γ干扰素和MIP-1β，并表现出抗病毒细胞毒性活性。

J Virol. 1998 Aug;72(8):6421-9. doi: 10.1128/JVI.72.8.6421-6429.1998.

本文引用的文献

Interleukin-12 (IL-12) production in whole blood cultures from human immunodeficiency virus-infected individuals studied in relation to IL-10 and prostaglandin E2 production.在对感染人类免疫缺陷病毒个体的全血培养物中白细胞介素-12（IL-12）的产生进行研究时，将其与IL-10和前列腺素E2的产生相关联。

Blood. 1997 Jan 15;89(2):570-6.

Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.对来自HIV感染者的T细胞产生白细胞介素-4和干扰素-γ的单细胞分析：在白细胞介素-4产生保持的情况下，干扰素-γ减少。

J Immunol. 1996 Sep 15;157(6):2712-8.

Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection.在HIV感染期间，潜在细胞毒性CD8 + T淋巴细胞中与Bcl-2体外下调和Fas上调相关的细胞凋亡。

J Immunol. 1996 Mar 15;156(6):2282-93.

Temporal relationship between elongation of the HIV type 1 glycoprotein 120 V2 domain and the conversion toward a syncytium-inducing phenotype.1型人类免疫缺陷病毒糖蛋白120 V2结构域延长与向合胞体诱导表型转化之间的时间关系。

AIDS Res Hum Retroviruses. 1995 Dec;11(12):1473-8. doi: 10.1089/aid.1995.11.1473.

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.白细胞介素-12诱导人T细胞产生白细胞介素-10作为对白细胞介素-12诱导的免疫反应的负反馈。

J Immunol. 1996 Apr 15;156(8):2776-82.

Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.尽管有多次高危性接触但仍未感染的个体的CD4淋巴细胞对HIV-1感染的相对抗性。

Nat Med. 1996 Apr;2(4):412-7. doi: 10.1038/nm0496-412.

Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection.1型人类免疫缺陷病毒感染过程中细胞负荷变化、病毒表型演变与病毒群体克隆组成之间的关系。

J Infect Dis. 1996 Feb;173(2):349-54. doi: 10.1093/infdis/173.2.349.

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.鉴定RANTES、MIP-1α和MIP-1β为CD8 + T细胞产生的主要HIV抑制因子。

Science. 1995 Dec 15;270(5243):1811-5. doi: 10.1126/science.270.5243.1811.

HIV suppression by interleukin-16.白细胞介素-16对HIV的抑制作用。

Nature. 1995 Dec 7;378(6557):563. doi: 10.1038/378563a0.

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes.人类免疫缺陷病毒在人巨噬细胞中上调Fas配体表达，介导未感染T淋巴细胞的凋亡。

J Virol. 1996 Jan;70(1):199-206. doi: 10.1128/JVI.70.1.199-206.1996.

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Immune dysregulation and CD4+ T cell loss in HIV-1 infection.

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