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第二次欧洲急性冠状动脉综合征调查:2004年欧洲及地中海地区急性冠状动脉综合征患者的特征、治疗及转归

The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004.

作者信息

Mandelzweig Lori, Battler Alex, Boyko Valentina, Bueno Hector, Danchin Nicolas, Filippatos Gerasimos, Gitt Anselm, Hasdai David, Hasin Yonathan, Marrugat Jaume, Van de Werf Frans, Wallentin Lars, Behar Shlomo

机构信息

Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Eur Heart J. 2006 Oct;27(19):2285-93. doi: 10.1093/eurheartj/ehl196. Epub 2006 Aug 14.

Abstract

AIMS

Our study aimed to examine the management of acute coronary syndromes (ACS) in Europe and the Mediterranean basin, and to compare adherence to guidelines with that reported in the first Euro Heart Survey on ACS (EHS-ACS-I), 4 years earlier.

METHODS AND RESULTS

In a prospective survey conducted in 2004 (EHS-ACS-II), data describing the characteristics, treatment, and outcome of 6385 patients diagnosed with ACS in 190 medical centres in 32 countries were collected. ACS with ST-elevation was the initial diagnosis in 47% of patients, no ST-elevation in 48%, and undetermined electrocardiographic pattern in 5% of patients. Comparison of data collected in 2000 and 2004 showed similar baseline characteristics, but greater use of recommended medications and coronary interventions in EHS-ACS-II. Among patients with ST-elevation, the use of primary reperfusion increased slightly (from 56 to 64%), with a significant shift from fibrinolytic therapy to primary percutaneous coronary intervention (PPCI). The use of PPCI rose from 37 to 59% among those undergoing primary reperfusion therapy. Analysis of data in 34 centres that participated in both surveys showed even greater improvement with respect to the use of recommended medical therapy, interventions, and outcome.

CONCLUSION

Data from EHS-ACS-II suggest an increase in adherence to guidelines for treatment of ACS in comparison with EHS-ACS-I.

摘要

目的

我们的研究旨在调查欧洲和地中海地区急性冠状动脉综合征(ACS)的管理情况,并与4年前首次欧洲急性冠状动脉综合征心脏调查(EHS-ACS-I)报告的指南依从性进行比较。

方法与结果

在2004年进行的一项前瞻性调查(EHS-ACS-II)中,收集了32个国家190个医疗中心6385例诊断为ACS患者的特征、治疗及预后数据。47%的患者初始诊断为ST段抬高型ACS,48%为非ST段抬高型,5%为心电图模式未确定型。2000年和2004年收集的数据比较显示,基线特征相似,但EHS-ACS-II中推荐药物和冠状动脉介入治疗的使用更多。在ST段抬高型患者中,早期再灌注治疗的使用略有增加(从56%增至64%),且显著从溶栓治疗转向了直接经皮冠状动脉介入治疗(PPCI)。在接受早期再灌注治疗的患者中,PPCI的使用从37%升至59%。对参与两项调查的34个中心的数据分析显示,在推荐药物治疗、介入治疗及预后方面有更大改善。

结论

EHS-ACS-II的数据表明,与EHS-ACS-I相比,ACS治疗指南的依从性有所提高。

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