Whitwell Jennifer L, Warren Jason D, Josephs Keith A, Godbolt Alison K, Revesz Tamas, Fox Nick C, Rossor Martin N
Dementia Research Centre, Institute of Neurology, London, UK.
Neurodegener Dis. 2004;1(4-5):225-30. doi: 10.1159/000080990.
The identification of specific, diagnostically useful predictors of protein dysfunction in the frontotemporal lobar degenerations (FTLD) is a problem of great clinical and biological interest. Correlations between regional patterns of tissue loss and specific proteinopathies have not been established.
Specific brain imaging correlates of protein tau dysfunction were sought using voxel-based morphometry in FTLD subgroups with and without tau pathology.
Seventeen patients with pathologically or genetically confirmed diagnoses of FTLD who had undergone volumetric brain magnetic resonance imaging (MRI) were identified retrospectively and tau-positive (n = 9) and tau-negative (n = 8) subgroups were defined. MRI data were compared with healthy age- and sex-matched controls using voxel-based morphometry implemented in a statistical parametric mapping software package.
Compared with controls, tau-positive and tau-negative subgroups had extensive common areas of regional brain atrophy predominantly affecting the frontal and anterior temporal lobes. No specific brain imaging features were identified for either subgroup.
Patterns of frontotemporal atrophy do not predict the presence or absence of tau pathology; conversely, different immunohistochemical profiles are associated with similar patterns of regional vulnerability to neuronal loss in FTLD.
确定额颞叶变性（FTLD）中蛋白质功能障碍的特定诊断有用预测指标是一个具有重大临床和生物学意义的问题。组织丢失的区域模式与特定蛋白质病之间的相关性尚未确立。
在有和没有tau病理的FTLD亚组中，使用基于体素的形态测量法寻找蛋白质tau功能障碍的特定脑成像相关性。
回顾性确定17例经病理或基因确诊为FTLD且已接受脑容积磁共振成像（MRI）的患者，并定义tau阳性（n = 9）和tau阴性（n = 8）亚组。使用统计参数映射软件包中实现的基于体素的形态测量法，将MRI数据与年龄和性别匹配的健康对照进行比较。
与对照组相比，tau阳性和tau阴性亚组有广泛的共同脑区萎缩区域，主要影响额叶和颞叶前部。两个亚组均未发现特定的脑成像特征。
额颞叶萎缩模式不能预测tau病理的存在与否；相反，在FTLD中，不同的免疫组化特征与类似的区域神经元丢失易损模式相关。
