Isaacson P G, Chan J K, Tang C, Addis B J
Department of Histopathology, University College and Middlesex School of Medicine, London, England.
Am J Surg Pathol. 1990 Apr;14(4):342-51. doi: 10.1097/00000478-199004000-00005.
We describe two cases of primary low-grade B-cell lymphoma of the thymus that showed histological features of low-grade B-cell lymphoma arising in mucosa-associated lymphoid tissue (MALT). The appearances most closely resembled MALT lymphoma arising in myoepithelial sialadenitis (MESA). In both cases, the tumor was excised. In one case, there has been no recurrence in 4 years of follow-up without further treatment; in the second case, the tumor has involved an axillary lymph node. Immunohistochemistry showed light-chain restriction in both cases, and the B-cell phenotype was similar to that previously described in MALT lymphomas. The occurrence of MALT lymphoma in the thymus is consistent with the presence of mucosal structures (Hassall's corpuscles) and with recent descriptions of a native B-cell population in this organ. The relationship of this previously undescribed thymic low-grade B-cell MALT lymphoma arising in the thymus has not yet been clarified.
我们描述了两例原发性胸腺低度B细胞淋巴瘤，其组织学特征显示为黏膜相关淋巴组织（MALT）中发生的低度B细胞淋巴瘤。其表现与肌上皮涎腺炎（MESA）中发生的MALT淋巴瘤最为相似。两例肿瘤均已切除。一例在随访4年中未经进一步治疗无复发；另一例肿瘤累及腋窝淋巴结。免疫组化显示两例均有轻链限制，B细胞表型与先前报道的MALT淋巴瘤相似。胸腺中MALT淋巴瘤的发生与黏膜结构（哈氏小体）的存在以及该器官中天然B细胞群体的最新描述一致。胸腺中这种先前未描述的低度B细胞MALT淋巴瘤的关系尚未阐明。
