Murata Yoshifumi, Nagaki Kumiko, Kofuji Kyouko, Sanae Fujiko, Kontani Hitoshi, Kawashima Susumu
Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan.
J Biomater Sci Polym Ed. 2006;17(7):781-9. doi: 10.1163/156856206777656517.
A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid. For CS-CN prepared with cinnamic acid, the amount of CN released was 0.286 +/- 0.001 mmol/g CS-CN; the amount of taurocholate adsorbed was 0.284 +/- 0.003 mmol/g CS-CN. These two functions were recognized on alginate or pectin gel beads containing CS-CN. The amount of released CN was altered extensively by the species of CN used for gel-bead preparation. Results suggest that CS-CN is a candidate for complementary medicine to prevent lifestyle-related diseases.
制备了一种用肉桂酸和一种类似化合物（CN）处理过的壳聚糖（CS）粉末，即CS-CN。利用它在体外研究了CS-CN对胆汁酸的吸附以及CN的释放情况。当CS-CN浸泡在牛磺胆酸盐溶液中时，它会释放CN并同时吸附胆汁酸。对于用肉桂酸制备的CS-CN，释放的CN量为0.286±0.001 mmol/g CS-CN；吸附的牛磺胆酸盐量为0.284±0.003 mmol/g CS-CN。在含有CS-CN的海藻酸盐或果胶凝胶珠上也发现了这两种功能。用于制备凝胶珠的CN种类会极大地改变释放的CN量。结果表明，CS-CN是预防生活方式相关疾病的补充药物的一个候选物。
