Rugsarash Wilaiwan, Tungtrongchitr Rungsunn, Petmitr Songsak, Phonrat Benjaluck, Pongpaew Praneet, Harnroongroj Talabporn, Tungtrongchitr Anchalee
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Ratchathewi, Bangkok, Thailand.
Nutr Neurosci. 2006 Feb-Apr;9(1-2):93-8. doi: 10.1080/10284150600771777.
The study subjects were 192 overweight and obese Thais (BMI > 25.00 kg/m2), and 103 Thai controls (BMI = 18.50-24.99 kg/m2), whose ages ranged from 18-60 years. All subjects were evaluated for serum Alpha-2-macroglobulin (A2M), globulin, albumin concentration, and polymorphic variation in the A2M gene. Serum A2M and albumin were significantly lower in the overweight/obese group (P < 0.05). For the overweight/obese and control group, the median ages were 38 and 37 years, serum A2M 200.2; 252.0 (mg/L), albumin 4.4; 4.5 (g/dL), and globulin 3.0; 2.95 (g/dL), respectively. A2M deletion polymorphism genotyping showed no association between A2M deletion polymorphism and the two groupings. At serum A2M concentration < 250 mg/L, there was no relationship between A2M deletion polymorphism and age. Serum A2M had a significant negative correlation with age in all subjects (R = 0.09, P < 0.05). The results did not support the hypothesis that A2M deletion polymorphism is associated with a low A2M concentration in overweight/obese subjects. However, serum A2M had a significant negative correlation with age; serum A2M can possibly be used to indicate the aging of cells in vivo, including the brain. Further studies are needed to investigate other A2M genes located on chromosome 12 to prove A2M gene polymorphism's association with low serum A2M and aging.
研究对象为192名超重和肥胖的泰国人（BMI>25.00kg/m²）以及103名泰国对照者（BMI=18.50-24.99kg/m²），年龄在18至60岁之间。所有受试者均接受血清α-2-巨球蛋白（A2M）、球蛋白、白蛋白浓度以及A2M基因多态性变异的评估。超重/肥胖组的血清A2M和白蛋白显著降低（P<0.05）。超重/肥胖组和对照组的中位年龄分别为38岁和37岁，血清A2M分别为200.2；252.0（mg/L），白蛋白分别为4.4；4.5（g/dL），球蛋白分别为3.0；2.95（g/dL）。A2M缺失多态性基因分型显示A2M缺失多态性与两组之间无关联。在血清A2M浓度<250mg/L时，A2M缺失多态性与年龄之间无关系。在所有受试者中，血清A2M与年龄呈显著负相关（R=0.09，P<0.05）。结果不支持A2M缺失多态性与超重/肥胖受试者低A2M浓度相关的假设。然而，血清A2M与年龄呈显著负相关；血清A2M可能可用于指示体内细胞的衰老，包括脑细胞。需要进一步研究以调查位于12号染色体上的其他A2M基因，以证明A2M基因多态性与低血清A2M和衰老的关联。
