Bowker R M, Abhold R H
Department of Anatomy, Michigan State University, East Lansing 48824-1316.
Eur J Pharmacol. 1990 Jan 3;175(1):101-6. doi: 10.1016/0014-2999(90)90159-4.
Basal 5-hydroxytryptamine (5HT) and norepinephrine (NE) concentrations were measured in samples collected by in vivo dialysis of the rat dorsal horn. Infusion of KCl, glutamate, and NE by means of the dialysis probe increased NE, but decreased 5HT extracellular concentrations. In contrast, electrical stimulation of the nucleus raphe magnus increased the recovery of both NE and 5HT. These findings suggest differential regulation of noradrenergic and serotonergic nerve terminals modulating nociceptive neurotransmission within the dorsal horn.
通过对大鼠背角进行体内透析收集的样本中，测定了基础5-羟色胺（5HT）和去甲肾上腺素（NE）的浓度。通过透析探针注入氯化钾、谷氨酸和去甲肾上腺素可增加NE，但降低5HT的细胞外浓度。相反，中缝大核的电刺激增加了NE和5HT的回收率。这些发现表明，去甲肾上腺素能和5-羟色胺能神经末梢对背角内伤害性神经传递的调节存在差异。
