他汀类药物在心力衰竭中的作用：超越其降胆固醇作用。
The effect of statins in heart failure: beyond its cholesterol-lowering effect.
作者信息
Kurian Kizhake C, Rai Prithviraj, Sankaran Sunder, Jacob Binu, Chiong Jun, Miller Alan B
机构信息
Division of Cardiology, University of Florida Health Science Center-Jacksonville, Jacksonville, Florida 32223, USA.
出版信息
J Card Fail. 2006 Aug;12(6):473-8. doi: 10.1016/j.cardfail.2006.02.001.
BACKGROUND
Statins known as 3-hydroxyl-3-methyl-glutaryl-coenzyme A (HMG-CoA) are designed to lower plasma cholesterol levels. They are used to treat hypercholesterolemia, ischemic heart disease patients, heart transplant recipients, in prevention of Alzheimer's dementia, multiple sclerosis, and have also been shown to reduce cancer risk.
METHODS AND RESULTS
The idea of statin treatment in chronic heart failure is not well established. It has been shown to be beneficial in patients with ischemic heart disease with heart failure. Emerging trends show their usefulness in patients with nonischemic heart failure. Statins exhibit pleiotropic effects in stabilizing the atherosclerotic plaques, improvement of endothelial function, inhibition of cell migration and proliferation, and reduction of inflammation and oxidative stress. They also improve autonomic function with an increased parasympathetic drive, downregulate the angiotensin II type I receptors, and induce angiogenesis.
CONCLUSION
This article is a review on the current knowledge on statin use in heart failure.
背景
他汀类药物即3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，旨在降低血浆胆固醇水平。它们用于治疗高胆固醇血症、缺血性心脏病患者、心脏移植受者，预防阿尔茨海默病性痴呆、多发性硬化症，并且也已显示可降低癌症风险。
方法与结果
他汀类药物用于慢性心力衰竭治疗的观点尚未完全确立。已证明其对伴有心力衰竭的缺血性心脏病患者有益。新出现的趋势表明它们对非缺血性心力衰竭患者也有用。他汀类药物在稳定动脉粥样硬化斑块、改善内皮功能、抑制细胞迁移和增殖以及减轻炎症和氧化应激方面具有多效性作用。它们还通过增加副交感神经驱动力来改善自主神经功能，下调血管紧张素II 1型受体，并诱导血管生成。
结论
本文是一篇关于他汀类药物在心力衰竭中应用的当前知识综述。
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