Saffar J L, Colombier M L, Detienville R
Laboratoire de Physiopathologie Osseuse, Faculté de Chirurgie Dentaire, Université René Descartes (Paris-V), Montrouge, France.
J Periodontol. 1990 Apr;61(4):209-16. doi: 10.1902/jop.1990.61.4.209.
The capacity of a tricalcium phosphate (TCP) ceramic to promote bone formation after grafting in intrabony defects was studied in humans. Five biopsies were collected from 4 patients during reentry surgery 16 to 40 months after implantation. They were processed without demineralization for histological examination. In the less mature samples, the grafted material was surrounded by a highly fibrous, highly cellular, and poorly vascularized connective tissue. Howship's lacuna-like cavities were clearly visible at the surface of the material. They contained resorbing mononuclear phagocytes. At a more mature stage, TCP granules were embedded in an acellular fibrous material which underwent mineralization from the medullary spaces towards the granules. The bone formed was subsequently remodeled. The implanted material itself was progressively modified. It first acquired the staining appearance of bone. After its structure became loose and vacuolated, it was invaded by cells and vessels. The present data indicate that TCP has osteogenic potential and is subject to degradation. Unlike in experimental wounds, these processes are of long duration in human defects.
在人体中研究了磷酸三钙（TCP）陶瓷植入骨内缺损后促进骨形成的能力。在植入后16至40个月的再次手术期间，从4名患者身上采集了5份活检样本。对其进行处理时未进行脱矿处理以进行组织学检查。在不太成熟的样本中，移植材料被高度纤维化、细胞丰富且血管化不良的结缔组织包围。在材料表面清晰可见类Howship腔隙。其中含有正在吸收的单核吞噬细胞。在更成熟的阶段，TCP颗粒嵌入无细胞纤维材料中，该材料从骨髓腔向颗粒进行矿化。随后形成的骨进行了重塑。植入材料本身逐渐发生改变。它首先呈现出骨的染色外观。在其结构变得疏松和空泡化后，被细胞和血管侵入。目前的数据表明TCP具有成骨潜力且会发生降解。与实验性伤口不同，这些过程在人类缺损中持续时间较长。
