Wu Mian-Bin, Ma Shu-Zhen
Bioengineering Institute, College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China.
Zhong Yao Cai. 2006 Apr;29(4):329-31.
To study on the 10-deacetyl baccatin III extract from the leaves and branches of Taxus mairei. A new method was proposed to extract and purify 10-DAB III, which was adopted as the parent nucleus of the high efficacious antitumour drug-taxol and docetaxel in the compositive synthesis. Optimization selection was also made in the extraction and purification conditions of taxol. The purity quotient of 10-DAB III obtained via this technics could reach 91%, with the yield above 70%. It has been testified that the technics was feasible in industrial practice.
对南方红豆杉枝叶中10 - 去乙酰巴卡亭III提取物进行研究。提出了一种提取和纯化10 - 去乙酰巴卡亭III的新方法，该物质在全合成中作为高效抗肿瘤药物紫杉醇和多西他赛的母核。对紫杉醇的提取和纯化条件也进行了优化筛选。通过该工艺获得的10 - 去乙酰巴卡亭III纯度可达91%，收率在70%以上。经证实，该工艺在工业生产中是可行的。
