Sinha S, Brady M, Scott C A, Walker M C
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1076-8. doi: 10.1136/jnnp.2006.088385.
To determine the effects of sleep and wakefulness on seizures in patients with refractory epilepsy recorded while undergoing video-electroencephalography (EEG) telemetry.
The video-EEG data of patients who had two or more seizures during video-EEG telemetry (n = 270) were reviewed. Fifty seven patients who had seizures both in wakefulness and sleep were identified. The video and ictal EEG data were reviewed, paying specific attention to type of seizures, duration, semiology, lateralisation and number of seizures.
Three hundred and sixty two seizures were recorded; 237 seizures while awake and 125 while sleeping. Secondary generalisation occurred more often in sleep than in wakefulness (p < 0.01). Overall, there was no significant effect of sleep on the duration of seizures or ictal EEG change. Sleep and awake seizures differed in only eight patients.
Secondary generalisation occurred more often in sleep than in wakefulness, perhaps due to the facilitated spread of seizures during sleep. For the most part, however, seizures recorded during sleep did not differ from those recorded during wakefulness.
确定睡眠和觉醒对难治性癫痫患者在视频脑电图（EEG）遥测记录期间癫痫发作的影响。
回顾了在视频脑电图遥测期间发生两次或更多次癫痫发作的患者（n = 270）的视频脑电图数据。确定了57名在觉醒和睡眠中均有癫痫发作的患者。回顾了视频和发作期脑电图数据，特别关注癫痫发作的类型、持续时间、症状学、定位和发作次数。
记录到362次癫痫发作；清醒时发作237次，睡眠时发作125次。继发性全面性发作在睡眠中比在觉醒中更常见（p < 0.01）。总体而言，睡眠对癫痫发作持续时间或发作期脑电图变化没有显著影响。仅8名患者的睡眠和清醒发作有所不同。
继发性全面性发作在睡眠中比在觉醒中更常见，可能是由于睡眠期间癫痫发作的扩散更容易。然而，在大多数情况下，睡眠期间记录的癫痫发作与觉醒期间记录的癫痫发作没有差异。
