Suzuki Suzuko, Sakai Osamu, Jara Hernán
Boston University Medical Center, Boston University, Boston, MA 02118, USA.
Magn Reson Imaging. 2006 Sep;24(7):877-87. doi: 10.1016/j.mri.2006.04.011. Epub 2006 May 26.
The combined T1, T2 and secular-T2 pixel frequency distributions of 24 adult human brains were studied in vivo using a technique based on the mixed-TSE pulse sequence, dual-space clustering segmentation and histogram gaussian decomposition. Pixel frequency histograms of whole brains and the four principal brain compartments were studied comparatively and as function of age. For white matter, the position of the T1 peak correlates with age (R2 =.7868) when data are fitted to a quadratic polynomial. For gray matter, a weaker age correlation is found (R2 =.3687). T2 and secular-T2 results are indicative of a weaker correlation with age. The technique and preliminary results presented herein may be useful for characterizing normal as well as abnormal aging of the brain, and also for comparison with the results obtained with alternative quantitative MRI methodologies.
采用基于混合快速自旋回波脉冲序列、双空间聚类分割和直方图高斯分解的技术，对24例成人大脑的T1、T2和长期T2像素频率分布进行了活体研究。对全脑和四个主要脑区的像素频率直方图进行了比较研究，并将其作为年龄的函数进行分析。对于白质，当数据拟合二次多项式时，T1峰值的位置与年龄相关（R2 = 0.7868）。对于灰质，发现年龄相关性较弱（R2 = 0.3687）。T2和长期T2结果表明与年龄的相关性较弱。本文介绍的技术和初步结果可能有助于表征大脑的正常和异常老化，也有助于与其他定量MRI方法获得的结果进行比较。
