Dosman J A, Fukushima Y, Senthilselvan A, Kirychuk S P, Lawson J A, Pahwa P, Cormier Y, Hurst T, Barber E M, Rhodes C S
Institute of Agricultural Rural and Environmental Health, IAREH, University of Saskatchewan, Saskatoon, Canada.
Am J Ind Med. 2006 Sep;49(9):761-6. doi: 10.1002/ajim.20339.
It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV(1) response following swine barn exposure.
Naïve males were tested at baseline, low and high endotoxin and dust levels. Subjects were classified as "more responsive" (n = 9) or "less responsive" (n = 11) based on FEV(1) reduction following high endotoxin exposure. Health measures included pulmonary function testing, blood samples and nasal lavage. Environmental samples were collected from the barn.
White blood cells and blood lymphocytes at low exposure were significantly greater in those who were "more responsive" compared to those who were "less responsive". There was a significant increase in blood lymphocytes, serum IL6, total nasal lavage cells and nasal IL8 at high exposure among "more responsive" subjects compared to "less responsive" subjects.
Respiratory response to high-level endotoxin and dust exposure predicts evidence of inflammatory response throughout a range of endotoxin and dust exposures.
研究表明，在猪舍设施中暴露于高浓度环境与呼吸道症状增加及肺功能下降有关。本研究调查了猪舍暴露后，能否通过第一秒用力呼气容积（FEV₁）反应预测全身反应。
对未接触过相关物质的男性在基线、低内毒素和高内毒素及粉尘水平下进行测试。根据高内毒素暴露后FEV₁的降低情况，将受试者分为“反应较强”组（n = 9）和“反应较弱”组（n = 11）。健康指标包括肺功能测试、血液样本采集和鼻腔灌洗。从猪舍采集环境样本。
与“反应较弱”的受试者相比，“反应较强”的受试者在低暴露水平时的白细胞和血液淋巴细胞数量显著更多。与“反应较弱”的受试者相比，“反应较强”的受试者在高暴露水平时血液淋巴细胞、血清白细胞介素-6、鼻腔灌洗细胞总数和鼻腔白细胞介素-8均显著增加。
对高水平内毒素和粉尘暴露的呼吸道反应可预测在一系列内毒素和粉尘暴露情况下的炎症反应证据。
