Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour R A
School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK.
J Oral Pathol Med. 2006 Sep;35(8):461-5. doi: 10.1111/j.1600-0714.2006.00433.x.
The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) preparation (0.2%) in the management of recurrent aphthous ulceration (RAU).
One hundred and twenty patients with RAU participated in a randomized, placebo controlled, double-blind trial to evaluate the efficacy of the topical HA and preparation. Outcome measures include soreness relief on immediate application (recorded over 60 min). Thereafter, patients completed a log diary recording soreness from the ulcers, occurrence of new ulcers and ulcer duration.
Both topical HA and placebo resulted in a significant reduction in ulcer soreness following immediate application (P = 0.0004). Throughout the rest of the investigation period, there was no significant differences (P > 0.05) between the treatments for reducing soreness. Patients treated with topical HA recorded few ulcers on day 5 of the investigation than those treated with placebo (P < 0.001). Likewise, the occurrence of new ulcers was lower in the HA treated group on day 4 when compared with placebo (P = 0.047).
Topical HA (0.2%) may be of benefit in the management of RAU. Immediate reduction of symptoms appears to be a barrier effect.
本研究旨在评估局部应用透明质酸（HA，0.2%）制剂治疗复发性阿弗他溃疡（RAU）的疗效。
120例RAU患者参与了一项随机、安慰剂对照、双盲试验，以评估局部应用HA制剂的疗效。观察指标包括即刻应用时疼痛缓解情况（记录60分钟内）。此后，患者完成一份日志，记录溃疡疼痛、新溃疡的出现及溃疡持续时间。
局部应用HA和安慰剂后，即刻应用时溃疡疼痛均显著减轻（P = 0.0004）。在整个其余研究期间，两种治疗方法在减轻疼痛方面无显著差异（P > 0.05）。在研究第5天，局部应用HA治疗的患者记录的溃疡数少于安慰剂治疗的患者（P < 0.001）。同样，在第4天，HA治疗组新溃疡的发生率低于安慰剂组（P = 0.047）。
局部应用HA（0.2%）可能对RAU的治疗有益。症状的即刻减轻似乎是一种屏障效应。
