Preshaw Philip M, Grainger Paula, Bradshaw Mark H, Mohammad Abdel R, Powala Chris V, Nolan Anita
Newcastle University School of Dental Sciences, Newcastle, UK.
J Oral Pathol Med. 2007 Apr;36(4):236-40. doi: 10.1111/j.1600-0714.2007.00507.x.
Recurrent oral aphthous ulceration (ROAU) is a common problem that can result in considerable pain and distress for patients. The aim of this pilot study was to evaluate the role of subantimicrobial dose doxycycline (SDD - 20 mg doxycycline twice daily) in the management of patients with ROAU.
50 patients with ROAU were randomly allocated to treatment with SDD or placebo for 90 days. Daily ulcer diaries were completed by the participants to record the number of new ulcers and the pain associated with the ulcers.
There were significantly more days with no new ulcers in the SDD group (80.4 +/- 5.9) than the placebo group (69.8 +/- 18.7; P=0.04). Strong trends were observed towards fewer new ulcers per day, fewer new ulcers over the 90-day period, and more days with no pain in the SDD group compared with the placebo group (P=0.06-0.08).
SDD shows promise as potential therapy in the management of ROAU, though this needs to be confirmed in further studies.
复发性口腔溃疡（ROAU）是一个常见问题，会给患者带来相当大的疼痛和困扰。这项初步研究的目的是评估亚抗菌剂量强力霉素（SDD - 20毫克强力霉素，每日两次）在ROAU患者治疗中的作用。
50例ROAU患者被随机分配接受SDD或安慰剂治疗90天。参与者完成每日溃疡日记，记录新溃疡的数量以及与溃疡相关的疼痛。
SDD组无新溃疡的天数（80.4±5.9）显著多于安慰剂组（69.8±18.7；P = 0.04）。与安慰剂组相比，观察到SDD组有每日新溃疡更少、90天内新溃疡更少以及无疼痛天数更多的强烈趋势（P = 0.06 - 0.08）。
SDD显示出作为ROAU治疗潜在疗法的前景，不过这需要在进一步研究中得到证实。
