Zang Yu-Feng, He Yong, Zhu Chao-Zhe, Cao Qing-Jiu, Sui Man-Qiu, Liang Meng, Tian Li-Xia, Jiang Tian-Zi, Wang Yu-Feng
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Brain Dev. 2007 Mar;29(2):83-91. doi: 10.1016/j.braindev.2006.07.002. Epub 2006 Aug 17.
In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0+/-1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, [corrected] and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.
在患有注意力缺陷多动障碍（ADHD）的儿童中，功能性神经影像学研究已经揭示了包括前额叶 - 纹状体回路、小脑和脑干在内的各个脑区存在异常。在本研究中，我们使用了一种新的功能磁共振成像（fMRI）标记物，即低频（0.01 - 0.08Hz）波动幅度（ALFF）来研究该疾病的基线脑功能。对13名患有ADHD的男孩（13.0±1.4岁）进行了静息态fMRI检查，并与年龄匹配的对照组进行比较。结果，我们发现ADHD患者右侧额下回、[校正后]双侧小脑和蚓部的ALFF降低，而右侧前扣带回皮质、左侧感觉运动皮质和双侧脑干的ALFF增加。这项静息态fMRI研究表明，这些区域自发神经元活动的改变可能与ADHD儿童潜在的病理生理学有关。
