Ravna Aina Westrheim, Jaronczyk Malgorzata, Sylte Ingebrigt
Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5594-7. doi: 10.1016/j.bmcl.2006.08.028. Epub 2006 Aug 17.
A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters from Aquifex aeolicus (LeuT(Aa)). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.
基于嗜热栖热菌（Aquifex aeolicus）中Na(+)/Cl(-)依赖性神经递质转运体的细菌同源物LeuT(Aa)的晶体结构，构建了人类血清素转运体（SERT）模型。ICM口袋发现器预测的配体结合区域中的氨基酸包括Tyr95、Ala96、Asp98、Gly100（跨膜螺旋（TMH）1）、Ala169、Ile172、Ala173、Tyr176（TMH3）、Phe335、Ser336、Gly338、Phe341、Val343（TMH6）、Thr439、Ala441和Gly442（TMH8）。本模型是用于SERT实验研究的更新的工作工具。
