Rudnick Gary
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520-8066, USA.
ACS Chem Biol. 2007 Sep 21;2(9):606-9. doi: 10.1021/cb7001818.
LeuT is a bacterial amino acid transporter belonging to a large family of membrane proteins, including the neurotransmitter transporters that are targets for antidepressant drugs. The high-resolution structure of LeuT has provided an important model for understanding structure and function in this family. Two recent papers found that LeuT can bind tricyclic antidepressants, raising the possibility that it may also serve as a model for the pharmacological properties of neurotransmitter transporters.
亮氨酸转运蛋白（LeuT）是一种细菌氨基酸转运体，属于一大类膜蛋白家族，其中包括作为抗抑郁药物作用靶点的神经递质转运体。LeuT的高分辨率结构为理解该家族的结构和功能提供了重要模型。最近的两篇论文发现LeuT能结合三环类抗抑郁药，这增加了它也可能作为神经递质转运体药理学特性模型的可能性。
