Ekberg J, Adams D J
School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Int J Biochem Cell Biol. 2006;38(12):2005-10. doi: 10.1016/j.biocel.2006.06.008. Epub 2006 Jul 12.
Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.
电压门控钠通道（VGSCs）在神经元兴奋性中起重要作用。VGSC 活性的调节是一种复杂的现象，发生在细胞的多个层面，包括转录调节、翻译后修饰以及膜插入和回收。存在多种 VGSC 亚型，它们在生物物理和药理特性以及组织分布上有所不同。神经元的 VGSC 亚型谱或调节 VGSC 活性的机制的任何改变都可导致神经元兴奋性的显著变化。炎症性和神经性疼痛状态的特征是感觉神经元中 VGSC 亚型组成和活性的改变。本综述重点关注参与此类疼痛状态的 VGSC 亚型。
