冠状动脉慢血流患者的P波时限与离散度及其与心肌梗死溶栓帧数的关系
P-wave duration and dispersion in patients with coronary slow flow and its relationship with Thrombolysis in Myocardial Infarction frame count.
作者信息
Dogan Sait M, Yildirim Nesligul, Gursurer Metin, Aydin Mustafa, Kalaycioglu Ezgi, Cam Fatih
机构信息
Department of Cardiology, Zonguldak Karaelmas University Medical Faculty, Kozlu, 67600 Zonguldak, Turkey.
出版信息
J Electrocardiol. 2008 Jan-Feb;41(1):55-9. doi: 10.1016/j.jelectrocard.2006.06.004. Epub 2006 Aug 21.
AIM
P-wave dispersion (PD), and duration has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The aim of this study was to investigate the PD in patients with coronary slow flow (CSF) phenomenon.
METHODS
Study population included 48 patients with angiographically proven normal coronary arteries and slow coronary flow in all 3 coronary vessels (group I, 36 men; mean age, 54 +/- 9 years) and 32 subjects with angiographically proven normal coronary arteries without associated slow coronary flow (group II, 24 men, mean age, 53 +/- 10 years). Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction (TIMI) frame count. All patients in group I had TIMI frame counts greater than 2 SD above those of control subjects (group II). The mean TIMI frame count for each patient and control subject was calculated by adding the TIMI frame counts for each major epicardial coronary artery and then dividing the obtained value into 3. The maximum and minimum P-wave duration (P(max) and P(min)) and PD were measured from the 12-lead surface electrocardiogram. Echocardiographic examination was also performed.
RESULTS
There was no statistically significant difference between the 2 groups with respect to age, sex, hypertension, diabetes mellitus, hyperlipidemia, and cigarette smoking (P > .05). P-wave dispersion and P(max) of patients with CSF were found to be significantly higher than those of control subjects (39.4 +/- 17 vs 21.2 +/- 10 milliseconds and 121.6 +/- 17.1 vs 104.3 +/- 10.4 milliseconds, respectively; P < .0001). Moreover, we found a significant positive correlation between both P(max) and PD with mean TIMI frame count (r = 0.836 and r = 0.806, respectively; P < .0001).
CONCLUSIONS
P-wave dispersion and P-wave duration both were found to be greater in patients with CSF than in controls.
目的
据报道，P波离散度（PD）和时限与窦性冲动的不均匀及不连续传导有关。本研究旨在调查冠状动脉慢血流（CSF）现象患者的P波离散度。
方法
研究人群包括48例经血管造影证实冠状动脉正常但所有3支冠状动脉血流缓慢的患者（I组，36例男性；平均年龄54±9岁）和32例经血管造影证实冠状动脉正常且无相关冠状动脉慢血流的受试者（II组，24例男性，平均年龄53±10岁）。所有患者和对照受试者的冠状动脉血流速度通过心肌梗死溶栓（TIMI）帧数记录。I组所有患者的TIMI帧数比对照受试者（II组）高出2个标准差以上。通过将各主要心外膜冠状动脉的TIMI帧数相加，然后将所得值除以3来计算每个患者和对照受试者的平均TIMI帧数。从12导联体表心电图测量最大和最小P波时限（P（max）和P（min））以及P波离散度。还进行了超声心动图检查。
结果
两组在年龄、性别、高血压、糖尿病、高脂血症和吸烟方面无统计学显著差异（P>.05）。发现CSF患者的P波离散度和P（max）显著高于对照受试者（分别为39.4±17与21.2±10毫秒和121.6±17.1与104.3±10.4毫秒；P<.0001）。此外，我们发现P（max）和PD与平均TIMI帧数均呈显著正相关（分别为r = 0.836和r = 0.806；P<.0001）。
结论
发现CSF患者的P波离散度和P波时限均大于对照组。
Zotero 插件