Bai Ni, Khazaei Majid, van Eeden Stephan F, Laher Ismail
University of British Columbia, Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.
Pharmacol Ther. 2007 Jan;113(1):16-29. doi: 10.1016/j.pharmthera.2006.06.005. Epub 2006 Aug 21.
Since the London fog of 1952, in which more than 4000 people were killed in 4 days, the combined efforts of scientists from several disciplines, including those from the environmental health, clinical and biomedical disciplines, have raised serious concerns about the impact of air pollutants on human health. These environmental pollutants are rapidly being recognized as important and independent risk factors for several diseases such as asthma, chronic obstructive pulmonary disease, lung cancer, atherosclerosis, ischemic heart disease and stroke. Although the relative effects of particulate matter air pollution (aerodynamic diameter <10 microm, or PM(10)) are greater for respiratory than for cardiovascular deaths, the number of deaths attributable to PM(10) is much larger for cardiovascular than for respiratory reasons due to the higher prevalence of cardiovascular disease in the general population. This review summarizes current understanding of the mechanisms underlying the associations between PM(10) exposure and cardiovascular morbidity and mortality.
自1952年伦敦大雾事件（4天内有4000多人丧生）以来，包括环境卫生、临床和生物医学等多个学科的科学家共同努力，对空气污染物对人类健康的影响提出了严重关切。这些环境污染物正迅速被确认为引发多种疾病的重要独立风险因素，如哮喘、慢性阻塞性肺疾病、肺癌、动脉粥样硬化、缺血性心脏病和中风。尽管颗粒物空气污染（空气动力学直径<10微米，即PM(10)）对呼吸系统死亡的相对影响大于对心血管系统死亡的影响，但由于普通人群中心血管疾病的患病率较高，PM(10)导致的心血管系统死亡人数远多于呼吸系统死亡人数。本综述总结了目前对PM(10)暴露与心血管发病率和死亡率之间关联的潜在机制的理解。
