Nwoye Luke O, Al-Shehri Mohammed A
Department of Physiology, King Khalid University, College of Medicine and Medical Sciences, Abha, Kingdom of Saudi Arabia.
J Egypt Public Health Assoc. 2005;80(1-2):153-68.
Cancer chemotherapy drugs, fluids and electrolytes are best dosed per square meter of body surface area (BSA). Since newborns have an exceptionally large surface to mass ratio, their BSA needs to be accurately estimated, if it is to serve as a safe denominator for drugs and fluids. In this study, BSA was measured directly in 15 full-term Saudi newborns, using a coating technique. The data was used to construct a BSA weight-length prediction formula. Mean body mass index (BMI +/-SD) of our subjects was 12.56 +/- 1.29 kg/m2 and surface to mass ratio, .068 +/- .005 m2/kg. The closest fit to measured values was given by the regression equation: BSA (m2) = 0.03614H(0.294)W(0.529) +/- 0.0027 (SEE) A simplified formula based on weight alone: BSA = 7.4 + 4.2W +/- 0.0022(SEE) was derived for bedside use, in urgent situations. Our formulae may be applicable to non-Saudi newborns, if as expected, body size and shape variations in different populations develop after birth.
癌症化疗药物、液体和电解质的最佳给药剂量是根据每平方米体表面积（BSA）来确定的。由于新生儿的表面积与体重之比特别大，如果要将其作为药物和液体安全给药的分母，就需要准确估算其体表面积。在本研究中，采用一种涂层技术直接测量了15名沙特足月新生儿的体表面积。这些数据被用于构建一个体表面积-体重-身长预测公式。我们研究对象的平均体重指数（BMI +/-标准差）为12.56 +/- 1.29 kg/m²，表面积与体重之比为0.068 +/- 0.005 m²/kg。与测量值拟合度最高的回归方程为：体表面积（m²）= 0.03614×身高（0.294）×体重（0.529） +/- 0.0027（标准误）。为满足紧急情况下床边使用的需求，还推导出了一个仅基于体重的简化公式：体表面积 = 7.4 + 4.2×体重 +/- 0.0022（标准误）。如果不同人群的体型和形状差异如预期在出生后才出现，我们的公式可能适用于非沙特新生儿。
