Ushuijima Yo, Okuyama Chio, Mori Satoru, Kubota Takao, Nakai Takako, Nishimura Tsunehiko
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.
Ann Nucl Med. 2006 Jul;20(6):425-9. doi: 10.1007/BF03027378.
Treatment with donepezil improves cognitive function of patients with Alzheimer's disease (AD) when compared to a placebo-controlled group. The purpose of this study was to investigate changes in regional cerebral blood flow (rCBF) of AD patients in short-term and long-term treatment with donepezil.
rCBF was measured by N-isopropyl-p-123I-iodoamphetamine (IMP) autoradiography method. CBF measurements were performed in 17 AD patients before treatment and after 3 months (short-term therapy) and 1 year (long-term therapy). Regions of interest were set at cerebral cortex and cerebellar hemisphere. We used absolute CBF and relative CBF expressed as ratio to cerebellar CBF.
Significant increases in relative rCBF were noted in the frontal, parietal and temporal lobes at the end of short-term therapy. rCBF was decreased after the long-term therapy, whereas rCBF was still increased to a slight extent, as compared with the pre-treatment levels. Absolute rCBF showed minimal change and a tendency to decline.
Relative rCBF significantly increased in the short-term donepezil therapy, while following the long-term therapy, rCBF decreased to the pre-treatment level.
与安慰剂对照组相比，多奈哌齐治疗可改善阿尔茨海默病（AD）患者的认知功能。本研究的目的是调查AD患者在多奈哌齐短期和长期治疗中脑局部血流量（rCBF）的变化。
采用N-异丙基-p-123I-碘安非他明（IMP）自显影法测量rCBF。对17例AD患者在治疗前、治疗3个月（短期治疗）和1年（长期治疗）后进行脑血流量测量。感兴趣区域设定在大脑皮质和小脑半球。我们使用绝对脑血流量和以与小脑脑血流量的比值表示的相对脑血流量。
短期治疗结束时，额叶、顶叶和颞叶的相对rCBF显著增加。长期治疗后rCBF下降，而与治疗前水平相比，rCBF仍有轻微增加。绝对rCBF变化极小且有下降趋势。
多奈哌齐短期治疗中相对rCBF显著增加，而长期治疗后，rCBF降至治疗前水平。
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