Furber A S, Maheswaran R, Newell J N, Carroll C
South East Sheffield Primary Care Trust, 9 Orgreave Road, Sheffield S13 9LQ, UK.
Sex Transm Infect. 2007 Feb;83(1):41-6. doi: 10.1136/sti.2005.019505. Epub 2006 Aug 21.
To systematically review the evidence of the relation between smoking tobacco and HIV seroconversion and progression to AIDS.
A systematic review was undertaken of studies to look at tobacco smoking as a risk factor for either HIV seroconversion or progression to AIDS.
Six studies were identified with HIV seroconversion as an outcome measure. Five of these indicated that smoking tobacco was an independent risk factor after adjusting for important confounders with adjusted odds ratios ranging from 1.6 to 3.5. 10 studies were identified using progression to AIDS as an end point of which nine found no relation with tobacco smoking.
Tobacco smoking may be an independent risk factor for HIV infection although residual confounding is another possible explanation. Smoking did not appear to be related to progression to AIDS although this finding may not be true in developing countries or with the longer life expectancies seen with highly active antiretroviral therapy.
系统回顾吸烟与HIV血清转化及发展为艾滋病之间关系的证据。
对将吸烟视为HIV血清转化或发展为艾滋病的危险因素的研究进行系统回顾。
确定了六项以HIV血清转化为结局指标的研究。其中五项表明，在对重要混杂因素进行调整后，吸烟是一个独立危险因素，调整后的优势比在1.6至3.5之间。确定了十项以发展为艾滋病为终点的研究，其中九项发现与吸烟无关。
吸烟可能是HIV感染的一个独立危险因素，尽管残余混杂是另一种可能的解释。吸烟似乎与发展为艾滋病无关，尽管这一发现可能在发展中国家不成立，或者在接受高效抗逆转录病毒治疗后预期寿命延长的情况下不成立。
