在人类感染期间，伤寒沙门氏菌血清型伤寒和副伤寒A有效产生细胞溶素A的血清学证据。
Serologic evidence for effective production of cytolysin A in Salmonella enterica serovars typhi and paratyphi A during human infection.
作者信息
von Rhein Christine, Hunfeld Klaus-Peter, Ludwig Albrecht
机构信息
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
出版信息
Infect Immun. 2006 Nov;74(11):6505-8. doi: 10.1128/IAI.00779-06. Epub 2006 Aug 21.
Abstract
ClyASTy and ClyASPaA are closely related pore-forming cytolysins of Salmonella enterica serovars Typhi and Paratyphi A whose expression is strongly repressed under standard in vitro growth conditions. We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection.
摘要
ClyASTy和ClyASPaA是伤寒沙门氏菌和甲型副伤寒沙门氏菌密切相关的成孔细胞溶素，在标准体外生长条件下其表达受到强烈抑制。我们在此表明，这些病原体引起的人类感染会引发针对ClyA的特异性抗体反应，表明感染期间毒素有效产生。
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