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在人类感染期间，伤寒沙门氏菌血清型伤寒和副伤寒A有效产生细胞溶素A的血清学证据。

Serologic evidence for effective production of cytolysin A in Salmonella enterica serovars typhi and paratyphi A during human infection.

作者信息

von Rhein Christine, Hunfeld Klaus-Peter, Ludwig Albrecht

机构信息

Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.

出版信息

Infect Immun. 2006 Nov;74(11):6505-8. doi: 10.1128/IAI.00779-06. Epub 2006 Aug 21.

DOI:10.1128/IAI.00779-06
PMID:16923786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1695487/
Abstract

ClyASTy and ClyASPaA are closely related pore-forming cytolysins of Salmonella enterica serovars Typhi and Paratyphi A whose expression is strongly repressed under standard in vitro growth conditions. We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection.

摘要

ClyASTy和ClyASPaA是伤寒沙门氏菌和甲型副伤寒沙门氏菌密切相关的成孔细胞溶素，在标准体外生长条件下其表达受到强烈抑制。我们在此表明，这些病原体引起的人类感染会引发针对ClyA的特异性抗体反应，表明感染期间毒素有效产生。

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本文引用的文献

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Typhoid and paratyphoid fever in travellers.旅行者中的伤寒和副伤寒热
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SlyA regulates function of Salmonella pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes.SlyA调节沙门氏菌致病岛2（SPI-2）的功能以及与SPI-2相关基因的表达。
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Molecular analysis of cytolysin A (ClyA) in pathogenic Escherichia coli strains.致病性大肠杆菌菌株中细胞溶素A（ClyA）的分子分析
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Transcriptional control of the antimicrobial peptide resistance ugtL gene by the Salmonella PhoP and SlyA regulatory proteins.沙门氏菌PhoP和SlyA调控蛋白对抗菌肽抗性ugtL基因的转录控制。
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PhoP-responsive expression of the Salmonella enterica serovar typhimurium slyA gene.鼠伤寒沙门氏菌slyA基因的PhoP应答性表达。
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Typhoid fever.伤寒热
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