Larsson L, Alumets J, Håkanson R, Simonsson M, Sundler F
Department of Medical Cell Research, University of Lund, Sweden.
Virchows Arch A Pathol Anat Histopathol. 1990;416(6):465-72. doi: 10.1007/BF01600296.
Some soluble proteins, such as the chromogranins, are found in nearly all peptide hormone-producing cells. Little is known about their functional role, although they may act as enzymes or represent structural proteins. In the present study we have isolated granules from an ileal carcinoid tumour and raised antibodies to protein constituents within them. The antiserum proved to be useful for the immunohistochemical demonstration of peptide hormone-producing endocrine tumours in general and for the demonstration of most peptide hormone-producing cells.
一些可溶性蛋白质，如嗜铬粒蛋白，几乎在所有产生肽类激素的细胞中都能找到。尽管它们可能作为酶发挥作用或代表结构蛋白，但其功能作用却鲜为人知。在本研究中，我们从回肠类癌肿瘤中分离出颗粒，并针对其中的蛋白质成分制备了抗体。该抗血清被证明一般可用于免疫组织化学显示产生肽类激素的内分泌肿瘤，以及显示大多数产生肽类激素的细胞。
