Hung L C, Wong S L, Chan L G, Rosli R, Ng A N A, Bresee J S
Institute of Paediatrics, Kuala Lumpur Hospital, 50586 Kuala Lumpur, Malaysia.
Int J Infect Dis. 2006 Nov;10(6):470-4. doi: 10.1016/j.ijid.2006.05.008.
The objectives of the study were to describe the epidemiology and strain characterization of rotavirus (RV), to determine the proportion of hospitalizations for diarrhea attributable to RV among children under 5 years of age, and to estimate the disease burden of RV diarrhea in Malaysia.
All children 0-59 months of age admitted for acute gastroenteritis to Kuala Lumpur Hospital (KLH) or Hospital Umum Sarawak (HUS) were surveyed. The periods of surveillance were from February 1, 2001 to April 30, 2003 in KLH and April 1, 2001 to March 31, 2003 for HUS.
The highest rate of RV-associated diarrhea was among children aged 6-17 months, accounting for 55% of RV-associated diarrhea. There was no seasonality observed in either hospital. P[8]G9 strains were predominant, accounting for 73% of all strains in both hospitals, 80% from KLH and 61% from HUS. There was no mortality.
RV was responsible for 38% of hospitalizations for diarrhea. It was most common in the 6-17 months age group. There was no seasonality observed for RV-associated diarrhea. The most prevalent strain of RV was P[8]G9. The estimated incidence of RV-associated diarrhea was 27 per 10000 population under the age of 5 years per year.
本研究的目的是描述轮状病毒（RV）的流行病学和毒株特征，确定5岁以下儿童因RV导致的腹泻住院比例，并估算马来西亚RV腹泻的疾病负担。
对入住吉隆坡医院（KLH）或砂拉越综合医院（HUS）的所有0 - 59个月因急性肠胃炎入院的儿童进行调查。KLH的监测期为2001年2月1日至2003年4月30日，HUS的监测期为2001年4月1日至2003年3月31日。
RV相关腹泻发生率最高的是6 - 17个月的儿童，占RV相关腹泻的55%。两家医院均未观察到季节性。P[8]G9毒株占主导，在两家医院的所有毒株中占73%，其中KLH占80%，HUS占61%。无死亡病例。
RV导致38%的腹泻住院病例。在6 - 17个月年龄组最为常见。RV相关腹泻未观察到季节性。最常见的RV毒株是P[8]G9。估计每年5岁以下人群中RV相关腹泻的发病率为每10000人27例。
