检测血液中的人细胞间黏附分子1有助于预测慢性丙型肝炎和肝硬化患者肝细胞癌的发生。

Measurement of human intercellular adhesion molecule 1 in the blood is useful for predicting the occurrence of hepatocellular carcinomas from chronic hepatitis C and liver cirrhosis.

作者信息

Moriyama Mitsuhiko, Matsumura Hiroshi, Shioda Jiro, Aoki Hiroshi, Nakamura Hitomi, Arakawa Yasuo, Nirei Kazushige, Yamagami Hiroaki, Kaneko Miki, Tanaka Naohide, Arakawa Yasuyuki

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Intervirology. 2006;49(6):327-38. doi: 10.1159/000095152. Epub 2006 Aug 21.

DOI:10.1159/000095152

PMID:16926545

Abstract

OBJECTIVE

We measured the concentrations of serum intercellular adhesion molecule 1 (sICAM-1) in patients with C-viral chronic liver diseases and started prospective studies immediately thereafter, in order to determine whether the concentration of sICAM-1 is useful for predicting the occurrence of hepatocellular carcinoma (HCC) following C-viral chronic hepatitis (CH) and liver cirrhosis (LC).

METHODS

We studied 74 patients with CH, 18 with LC, and 28 patients with HCC who visited our institute from 1993 through 1996. All were positive for hepatitis C virus RNA in the blood. The concentrations of sICAM-1 were measured using enzyme-linked immunosorbent assay kits. The expression of ICAM-1 in the liver was detected by indirect immunoperoxidase staining.

RESULTS

The concentrations of sICAM-1 were significantly higher in patients with LC and HCC than in patients with CH. The sICAM-1 concentrations were high in patients whose platelet counts were low. ICAM-1 in the liver was localized to the endoplasmic reticulum or the membrane of cancer cells. The cumulative rate of occurrence of HCC from CH or LC was significantly higher in the high-sICAM-1 group (>400 ng/ml) than in the low-sICAM-1 group. Multivariate analysis revealed that elevation of the sICAM-1 concentration is a significant risk factor for the occurrence of HCC.

CONCLUSION

Evaluation of the sICAM-1 concentration is useful for prediction of the occurrence of HCC in patients with C-viral CH or LC.

摘要

目的

我们测定了丙型病毒性慢性肝病患者血清细胞间黏附分子1（sICAM - 1）的浓度，并在此后立即开展前瞻性研究，以确定sICAM - 1浓度是否有助于预测丙型病毒性慢性肝炎（CH）和肝硬化（LC）后肝细胞癌（HCC）的发生。

方法

我们研究了1993年至1996年期间到我院就诊的74例CH患者、18例LC患者和28例HCC患者。所有患者血液中丙型肝炎病毒RNA均为阳性。使用酶联免疫吸附测定试剂盒测定sICAM - 1的浓度。通过间接免疫过氧化物酶染色检测肝脏中ICAM - 1的表达。

结果

LC和HCC患者的sICAM - 1浓度显著高于CH患者。血小板计数低的患者sICAM - 1浓度较高。肝脏中的ICAM - 1定位于内质网或癌细胞膜。高sICAM - 1组（>400 ng/ml）CH或LC后HCC的累积发生率显著高于低sICAM - 1组。多变量分析显示，sICAM - 1浓度升高是HCC发生的一个显著危险因素。