Lorini R, Cortona L, Scotta M S, Melzi d'Eril G V, Severi F
Department of Pediatrics, I.R.C.C.S., University of Pavia, Italy.
Diabetes Res Clin Pract. 1990 Mar;8(3):263-7. doi: 10.1016/0168-8227(90)90125-d.
Exocrine pancreatic function was evaluated in 21 diabetic children on the basis of a p-aminobenzoic acid (PABA) test and a determination of fasting serum amylase, pancreatic isoamylase, lipase, trypsin and elastase levels. Fecal chymotrypsin was also measured. Compared to the controls, the diabetic children had significantly lower levels of trypsin (P less than 0.001) and elastase (P less than 0.02). Fecal chymotrypsin appeared to be significantly lower (P less than 0.01) in diabetic children than in controls but in all patients fecal chymotrypsin values registered above the limit considered to be normal. No significant correlation was observed between pancreatic enzyme concentrations, serum and urinary PABA values, and chronologic age, HbA1 and insulin requirement. Only for serum PABA a significant negative correlation with duration of disease (P less than 0.01) has been observed. These data show that exocrine pancreatic function may be abnormal in children with IDDM.
基于对氨基苯甲酸（PABA）试验以及空腹血清淀粉酶、胰腺同工淀粉酶、脂肪酶、胰蛋白酶和弹性蛋白酶水平的测定，对21名糖尿病儿童的外分泌胰腺功能进行了评估。还测量了粪便糜蛋白酶。与对照组相比，糖尿病儿童的胰蛋白酶水平（P<0.001）和弹性蛋白酶水平（P<0.02）显著降低。糖尿病儿童的粪便糜蛋白酶似乎显著低于对照组（P<0.01），但所有患者的粪便糜蛋白酶值均高于被认为正常的限值。未观察到胰腺酶浓度、血清和尿液PABA值与实际年龄、糖化血红蛋白（HbA1）和胰岛素需求量之间存在显著相关性。仅观察到血清PABA与病程呈显著负相关（P<0.01）。这些数据表明，1型糖尿病儿童的外分泌胰腺功能可能异常。
