Woodcock Steven R, Marwitz Adam J V, Bruno Paulo, Branchaud Bruce P
Chemistry Department, University of Oregon, Eugene, OR 97403, USA.
Org Lett. 2006 Aug 31;8(18):3931-4. doi: 10.1021/ol0613463.
Unsaturated fatty acids are nitrated endogenously to produce nitrated lipids. Recent studies have shown that these nitrated lipids have high chemical reactivity and profound biological implications. We report an efficient, scalable synthesis which is regiospecific and stereoselective for all possible isomers of nitrated oleic acid: (E)- and (Z)-, 9- and 10-octadec-9-enoic acids.
不饱和脂肪酸在体内发生硝化反应生成硝化脂质。最近的研究表明，这些硝化脂质具有高化学反应活性并具有深远的生物学意义。我们报道了一种高效、可扩展的合成方法，该方法对硝化油酸的所有可能异构体具有区域选择性和立体选择性：（E）-和（Z）-、9-和10-十八碳-9-烯酸。
