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Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.硝酰基烯脂肪酸通过不同的信号通路并以显著不同的效力介导 Nrf2/ARE 依赖性和 PPARγ 依赖性转录的激活。
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本文引用的文献

1
Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands.一氧化氮信号的脂肪酸转导：人血液和尿液中存在多种硝化不饱和脂肪酸衍生物，并作为内源性过氧化物酶体增殖物激活受体配体发挥作用。
J Biol Chem. 2005 Dec 23;280(51):42464-75. doi: 10.1074/jbc.M504212200. Epub 2005 Oct 14.
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An introduction to NO-related therapeutic agents.一氧化氮相关治疗药物介绍。
Curr Top Med Chem. 2005;5(7):597-601. doi: 10.2174/1568026054679281.
3
Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation.硝化脂质分解为一氧化氮和脂质自由基，并引起血管舒张。
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Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor.一氧化氮信号的脂肪酸转导。硝基油酸是一种疏水稳定的一氧化氮供体。
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Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand.亚硝基油酸：一种内源性过氧化物酶体增殖物激活受体γ配体。
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Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation.红细胞膜和血浆亚油酸硝化产物：合成、临床鉴定及定量分析
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Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation.过氧化物酶体增殖物激活受体γ（PPARγ）配体作为细胞增殖的双功能调节剂。
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Tandem double intramolecular [4+2]/[3+2] cycloadditions of nitroalkenes. The fused/bridged mode.硝基烯烃的串联双分子内[4+2]/[3+2]环加成反应。稠合/桥连模式。
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Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation.过氧化物酶体增殖物激活受体：关于配体生成内源性途径的批判性综述。
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（E）-9-和（E）-10-硝基十八碳-9-烯酸的区域和立体特异性合成及其一氧化氮供体性质

Regio- and stereospecific syntheses and nitric oxide donor properties of (E)-9- and (E)-10-nitrooctadec-9-enoic acids.

作者信息

Gorczynski Michael J, Huang Jinming, King S Bruce

机构信息

Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA.

出版信息

Org Lett. 2006 May 25;8(11):2305-8. doi: 10.1021/ol060548w.

DOI:10.1021/ol060548w
PMID:16706512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3481162/
Abstract

[reaction: see text] Nitrated fatty acids act as endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) ligands and nitric oxide (NO) donors. We describe the first specific preparation of the two regioisomers of nitrooleic acid, (E)-9-nitrooctadec-9-enoic acid (1) and (E)-10-nitrooctadec-9-enoic acid (2), from cis-cyclooctene and monomethyl azelate, respectively. These syntheses rely upon a Henry condensation between a nine-carbon nitro component and a nine-carbon aldehyde. Preliminary chemiluminescence NO detection studies reveal the ability of these nitrated fatty acids to release NO.

摘要

[反应：见正文] 硝化脂肪酸作为内源性过氧化物酶体增殖物激活受体γ（PPARγ）配体和一氧化氮（NO）供体。我们分别描述了从顺式环辛烯和壬二酸单甲酯首次特异性制备硝基油酸的两种区域异构体，即（E）-9-硝基十八碳-9-烯酸（1）和（E）-10-硝基十八碳-9-烯酸（2）。这些合成方法依赖于九碳硝基组分与九碳醛之间的亨利缩合反应。初步的化学发光NO检测研究揭示了这些硝化脂肪酸释放NO的能力。