Intralesional therapy of metastatic spreading melanoma with beta-interferon.

A 74-year-old female patient developed multiple local metastases after excision of a nodular melanoma of the left cheek. There was no regression after treatment with dacarbazine (DTIC) and radiotherapy. After treatment with intralesional interferon-beta, the metastases regressed completely. The dosage was 5 million IU interferon-beta (Fiblaferon) three times weekly with courses of two and four weeks, separated by a month. Except for local swelling and inflammation, no side effects occurred. Five years after completing therapy, the patient is still tumor-free.