Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Clin Exp Dermatol. 2009 Oct;34(7):793-9. doi: 10.1111/j.1365-2230.2009.03207.x. Epub 2009 May 5.
Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-beta for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-beta injection. These results suggest that the peritumoral administration of IFN-beta enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.
先前针对各种治疗方法的试验并未显示出对恶性黑色素瘤（MM）皮肤转移的令人满意的治疗效果。我们报告了三例接受瘤周注射干扰素（IFN）-β治疗 MM 多发性皮肤转移的患者。转移性肿瘤浸润了大量的 CD8+TIA+细胞毒性淋巴细胞，并且在 IFN-β注射后 CD4+细胞和人类白细胞抗原-DR+细胞的数量增加。这些结果表明，瘤周给予 IFN-β增强了针对 MM 的抗肿瘤免疫反应，表明它是 MM 皮肤转移的一种有前途的支持性治疗方法。
