Isley William L, Park Youngsoon, Harris William S
Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Endocrine Research Unit, Rochester, MN 55905, USA.
Platelets. 2006 Aug;17(5):292-5. doi: 10.1080/09537100600746490.
Statins reduce coronary heart disease risk by altering blood lipids and other mechanisms. One of the possible other mechanisms is through an effect on thrombosis. We assessed the effect of simvastatin 80 mg daily versus placebo given in a single blind crossover fashion on platelet size in response to standard ex vivo stimuli, a surrogate for platelet activation, in 12 subjects with type 2 diabetes and mixed dyslipidemia. Exposure to collagen, cold, and heat caused the expected changes in platelet volume. Contrary to our expectations, ex vivo platelet size during collagen and cold exposure increased by 2.6 and 1.7%, respectively (P < 0.05), during simvastatin treatment as opposed to the placebo period. We conclude that some of the effects of high dose simvastatin therapy on platelets may not necessarily be anti-atherogenic.
他汀类药物通过改变血脂及其他机制降低冠心病风险。其他可能的机制之一是对血栓形成产生影响。我们采用单盲交叉方式，评估了每日服用80毫克辛伐他汀与服用安慰剂对12例2型糖尿病合并混合性血脂异常患者血小板大小的影响，血小板大小是体外标准刺激下血小板活化的替代指标。暴露于胶原蛋白、寒冷和热环境会引起血小板体积的预期变化。与我们的预期相反，在辛伐他汀治疗期间，与安慰剂期相比，暴露于胶原蛋白和寒冷环境时的体外血小板大小分别增加了2.6%和1.7%（P<0.05）。我们得出结论，高剂量辛伐他汀治疗对血小板的某些作用不一定具有抗动脉粥样硬化作用。
