Wiwanitkit Viroj
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ren Fail. 2006;28(6):457-9. doi: 10.1080/08860220600767327.
IgA nephropathy is the most common form of primary glomerulonephritis worldwide. The basic pathogenesis of this disease is believed to be due to the complex formation between Fc IgA, alphaRI (CD89), and transferrin receptor (CD71), leading to the damage of the glomerulus. However, studying the functional aberration in the human IgA, CD89, and CD71 complex formation in pathogenesis of IgA nephropathy is hard. Here, the author used a new gene ontology technology to predict the molecular function of human IgA, CD89, and CD71 complex. It can be seen that the two main functional aberrations of IgA-CD89 complex might be due to signal transduction and binding activity.
IgA肾病是全球原发性肾小球肾炎最常见的形式。该疾病的基本发病机制被认为是由于Fc IgA、αRI（CD89）和转铁蛋白受体（CD71）之间形成复合物，导致肾小球损伤。然而，研究IgA肾病发病机制中人类IgA、CD89和CD71复合物形成的功能异常很困难。在此，作者使用一种新的基因本体技术来预测人类IgA、CD89和CD71复合物的分子功能。可以看出，IgA-CD89复合物的两个主要功能异常可能是由于信号转导和结合活性。
