Yoder Katharine E, Shaffer Michele L, La Tournous Susan J, Paul Ian M
Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Clin Pediatr (Phila). 2006 Sep;45(7):633-40. doi: 10.1177/0009922806291014.
This study sought to investigate the efficacy of dextromethorphan (DM), diphenhydramine (DPH), and placebo (PL) for symptoms attributed to upper respiratory infections as determined by children, and to evaluate the concordance of perception of nocturnal symptoms between children and parents. A total of 37 children age 6 to 18 years of age were randomized in a double-masked fashion to receive a single bedtime dose of DM, DPH, or PL. Children found no significant difference in the effect of DM, DPH, or PL for any study outcome, and responses by parents and children were significantly correlated.
本研究旨在调查右美沙芬（DM）、苯海拉明（DPH）和安慰剂（PL）对儿童所认定的上呼吸道感染症状的疗效，并评估儿童与父母对夜间症状感知的一致性。共有37名6至18岁的儿童以双盲方式随机分组，接受单剂睡前服用的DM、DPH或PL。儿童发现DM、DPH或PL对任何研究结果的影响均无显著差异，且父母和儿童的反应显著相关。
