Meng Tian, Shi Bing, Zheng Qian, Wang Yan, Li Sheng
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Ann Plast Surg. 2006 Sep;57(3):264-9. doi: 10.1097/01.sap.0000221623.15710.b9.
The aim of our study was to review clinical and epidemiologic characteristic of the nonsyndromic cleft lip and cleft palate over a period of 10 years at West China Stomatological Hospital, Sichuan University. Four thousand two hundred sixty-eight nonsyndromic cleft lip and cleft palate cases were retrospectively analyzed according to the following variables: general information, cleft type, maternal age, familial history, as well as associated malformations, et al. In these cases, 1075 of which were cleft lip, 1985 were cleft lip with cleft palate; 1208 were isolated cleft palate. There were more men than women in the cleft lip and cleft lip with cleft palate group, while there were more women than men in the isolated cleft palate group. There were significantly more unilateral cleft lip cases than cleft lip on both sides; the cases of cleft lip on the left side were more than that of cleft lip on the right side. The cases with inherited history accounted for 6.68% of all the cases. Most infection cases occurred among the deleterious factors and the complications experienced during the first 3 months after the pregnancy. In all of the 14 twin cases, only 1 of the babies was affected. There were totally 152 cases with other associated malformations. Patients with cleft lip born in November to January were less than those born in the other three quarters of the year. Patients of A blood group composed a higher proportion than the control group. Our data may provide references for appropriate resource use, cleft lip and cleft palate prevention programs, and counseling programs with China-specific data.
我们研究的目的是回顾四川大学华西口腔医院10年间非综合征性唇腭裂的临床和流行病学特征。对4268例非综合征性唇腭裂病例按照以下变量进行回顾性分析：一般信息、腭裂类型、母亲年龄、家族史以及相关畸形等。在这些病例中，唇裂1075例，唇腭裂1985例，单纯腭裂1208例。唇裂及唇腭裂组男性多于女性，而单纯腭裂组女性多于男性。单侧唇裂病例明显多于双侧唇裂；左侧唇裂病例多于右侧唇裂。有遗传史的病例占所有病例的6.68%。大多数感染病例发生在有害因素及孕期前3个月出现的并发症中。在所有14例双胞胎病例中，只有1例婴儿患病。共有152例伴有其他相关畸形。11月至1月出生的唇裂患者少于一年中其他三个季度出生的患者。A型血患者所占比例高于对照组。我们的数据可为合理资源利用、唇腭裂预防项目以及具有中国特色数据的咨询项目提供参考。
