Semkina G A, Matsievskii D D, Mirzoyan N R
Laboratory for Pharmacology of Cerebrovascular Disorders, VV Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2006 Jan;141(1):51-2. doi: 10.1007/s10517-006-0091-6.
We compared the effects of a pyrrolidone-pyroglutamic acid composition and nimodipine on blood circulation in the middle cerebral artery in rats. The composition produced a strong effect on blood supply to the brain, stimulated blood flow in the middle cerebral artery (by 60 +/- 9%) and decreased blood pressure (by 25.0 +/- 2.7%). The cerebrovascular effects of this composition differed from those of nimodipine. Nimodipine not only increased middle cerebral artery blood flow, but also decreased cerebral blood flow in the early period after treatment.
我们比较了吡咯烷酮 - 焦谷氨酸组合物和尼莫地平对大鼠大脑中动脉血液循环的影响。该组合物对脑供血产生了强烈影响，刺激大脑中动脉的血流（增加60±9%）并降低血压（降低25.0±2.7%）。该组合物的脑血管效应与尼莫地平不同。尼莫地平不仅增加大脑中动脉血流量，而且在治疗后的早期还会降低脑血流量。
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