Lun'shina E V, Gan'shina T S, Makarova L M, Pogorelyĭ V E, Mirzoian R S
Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya Str. 8, Moscow, 125315, Russia.
Eksp Klin Farmakol. 2003 Jan-Feb;66(1):20-2.
A new drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats with global recurrent brain ischemia and in a model ischemic state under high radial gravitational overload. In the former case, the new drug increases the blood circulation in rats with the global ischemic damage to a greater extent than in the intact control group. Pretreatment with the pyroglutamic acid--pyrrolidone composition produced a 2-2.5-fold increase in the survival of rats in the ischemic state caused by the radial gravitational overload. The data obtained show evidence of a substantial neuroprotector action of the new drug composition.
一种含有焦谷氨酸和吡咯烷酮的新型药物组合物，对全脑反复缺血的大鼠以及处于高向心重力过载下的模拟缺血状态，均能产生显著的脑循环影响。在前一种情况下，这种新药能使全脑缺血损伤大鼠的血液循环比正常对照组有更大程度的增加。用焦谷氨酸 - 吡咯烷酮组合物进行预处理，可使因向心重力过载导致缺血状态下的大鼠存活率提高2至2.5倍。所获数据表明该新型药物组合物具有显著的神经保护作用。
