[Effect of pyrrolidone-2 on the cerebral circulation].

The ability of cyclic GABA derivative--pyrrolidone-2--to increase markedly cerebral blood flow both normally and in conditions of cerebral blood supply disturbances produced by unilateral 20-min ligation of a common carotid artery has been demonstrated. When pyrrolidone-2 administration accompanied bicuculline infusion (0.1 mg/kg) it did not provoke significant changes in the blood flow. Besides, bicuculline markedly weakened pyrrolidone-2 ability to relax the isolated grafts of cerebral arteries.