Mirzoian S A, Ordian M B, Balasanian M G
Biull Eksp Biol Med. 1987 Jan;103(1):64-5.
The ability of cyclic GABA derivative--pyrrolidone-2--to increase markedly cerebral blood flow both normally and in conditions of cerebral blood supply disturbances produced by unilateral 20-min ligation of a common carotid artery has been demonstrated. When pyrrolidone-2 administration accompanied bicuculline infusion (0.1 mg/kg) it did not provoke significant changes in the blood flow. Besides, bicuculline markedly weakened pyrrolidone-2 ability to relax the isolated grafts of cerebral arteries.
已证实，环状GABA衍生物——吡咯烷酮-2——在正常情况下以及在单侧颈总动脉结扎20分钟导致脑供血障碍的条件下，均能显著增加脑血流量。当给予吡咯烷酮-2的同时输注荷包牡丹碱（0.1毫克/千克）时，并未引起血流量的显著变化。此外，荷包牡丹碱显著削弱了吡咯烷酮-2使离体脑动脉移植物舒张的能力。
